Coursework Example | Topics and Well Written Essays - 1000 words - 1

Coursework lawsuitMore water is needed to break bonds as hydrate contains hydrogen bonds between the water molecules. anhydrous has faster dissolution rate forming a supersaturated solution within a shorter period of date (British pharmacopein, 2012).Theophylline is often manufactured in a modified anesthetise formulations because of its characteristic of having a narrow down therapeutic range. It is, thus, given at right doses. Modified push button formulation would provide need to be provided at every 12 hours of enough plasma concentration. Peak serum-theophylline concentration occurs 4 hours after ingestion, which way of life formulation can release the drug at the right time. An overdose may be toxic. This indicate that the formulation can provide constant release of the drug. (British Pharmacopein, 2012).Talc acts as a dissolution lag and as a lubricant, Povidine (k25) acts as binder, Hydroxyethylcellulose acts as a binder, with Nuelin SA, acting as a plasticizer and a s a surfactant (Raymond & Paul, 2012).Basing on the results in the spreadsheet, it is certain that Uniphyllin 300 mg had the slowest rate of release in different media (both HCL and orthophosphate dissolution buffer media). It was found out that Nueclin SA contained higher rate of release than Uniphyllin 300 in both phosphate and HCL buffer media. The percent release Uniphyllin 300mg in 0.1 HCL was 33.10% at clxxx min, whereas percentage release of Neulin SA 250 mg in 0.1 HCL was 60.12 percent at 180 min of Uniphyllin 300mg in phosphate buffer was 34.85% at 180min, while percentage release of Nuelin SA 250 in phosphate buffer was 67.12% at 180min (Raymond & Paul, 2012).From the results obtained, it is rather clear that Nuelin SA 250 displayed PH-dependant drug release rate. The PH dependent gradient release is due to cellulose acetate phthalate. Cellulose acetate phthalate is used as an enteric coating on capsules or the tablets so that they do not fade away until they are with in the stomach acidic juicesof